To investigate the relation between MRI and Echocardiography diagnosis of Isolated Ventricular Non-compaction Cardiomyopathy (IVNC).
METHOD AND MATERIALS
Seven patients suspected for non-compaction cardiomyopathy were investigated with MRI and echocardiography. The MRI protocol consisted a cine-Fiesta sequence (TR 3.4ms, TE 1.3ms, Flip angle 45, 8 shots, matrix 160x128, FoV 320 mm, slice thickness 8mm) in 2-chamber, 4-chamber and short axis orientation using a 1.5 T MRI system (GE, Signa CV/i, Milwaukee, WI) Two-dimensional echocardiography (2DE) was performed in standard orientations using a modern ultrasound system (Philips, Sonos 5500;Andover, MA). For contrast echocardiography (CE) a commercially available contrast agent (Sonovue, Barcco, Italy) was injected in an antecubetal vein. Regional prevalence of non-compaction was registrated for all techniques and non-compacted and compacted layers were measured.
All 7 patients completed the protocol without complications and with sufficient image quality for analysis. A very close correlation between all three techniques for regional involvement of the left ventricle was seen. Involvement of the apex was more frequently established with contrast echocardiography compared to MRI and 2D-echo. Mean non-compacted layer thickness in MRI, 2DE and CE were 15.0 ± 2.8mm, 14.1 ± 3.3mm and 14.4 ± 2.8mm respectively, while compacted layer thickness was 5.7 ± 0.9mm, 6.3 ± 1.0mm and 5.4 ± 5.4mm respectively. Using a Student T-test these differences were not significant. The mean ratio between non-compacted and compacted layers was less in 2DE compared to MRI (2.2 versus 2.6 p = 0.06) and CE (2.2 versus 2.6, p = 0.04)
MRI and echocardiography show a high correlation in the diagnosis of IVNC. In echocardiography contrast agents may be necessary for a reliable differentiation between the compacted and the non-compacted necessary for an accurate measurement of the ratio.